The damage of important components under blast loads can easily lead to the progressive collapse of reinforced concrete (RC) structures, causing property losses and endangering people"s lives and safety. Fiber reinforced polymer (FRP) materials are commonly used to enhance RC structures, but there is a lack of quantitative assessment on the FRP reinforcement to the collapse blast-resistant performance degradation of RC structures. From the perspective of the poor safety and low cost of explosion testing, based on the LS-DYNA software, the rubber pad to simulate the explosion loads acting on the surface of the structure through the drop hammer testing machine is proposed in the range of drop hammer impact velocities from 1m/s to 10m/s, which further established an empirical formula for predicting the explosion loads on the surface of the structure. The experimental data from existing literature have verified the correctness of the concrete substructure finite element numerical model based on the LS-DYNA platform, then the energy method is used to assess the contribution of CFRP reinforcement to the collapse blast-resistant performance of concrete substructures. The research results indicate that, compared to the unreinforced concrete substructure using CFRP, the contribution of CFRP to the shear model and bending model increased by 38.3% and 40.9%, respectively. At the same time, CFRP reinforced beams can significantly improve the vertical bearing capacity of RC substructures in the CAA stage under explosive loads, which will provide a theoretical basis for practical engineering CFRP reinforced blast resistant design.