To address control inaccuracies caused by nonlinear dynamics, friction disturbances, and response lag in an integrated electro-hydraulic brake system, this paper proposes a four-closed-loop pressure control strategy integrating enhanced sliding mode control, fuzzy active disturbance rejection control, and compensation techniques. A dynamic model of the IEHB system is established. The four-loop architecture (pressure, position, speed, current) is designed: the pressure loop uses an improved sliding mode controller for high-precision tracking; the position loop combines feedforward with a discrete PI controller to reduce lag; the speed loop employs Fuzzy-ADRC with a LuGre friction compensator to suppress nonlinear disturbances; and the current loop uses a discrete PI controller with parameter feedforward for rapid response. Co-simulation results show that the proposed strategy limits the master cylinder pressure steady-state error to ±0.5 bar, reduces position tracking deviation below 0.5 rad, and shortens pressure settling time after step commands to less than 0.05 s. The strategy significantly improves accuracy, dynamic response, and robustness of IEHB pressure buildup, providing technical support for high-performance braking control.