In order to study the influence of traveling wave effect on the seismic response of bridges, the relative movement method was adopted to analyze the acceleration history of a practical high pile continuous rigid frame bridge with spans of (70 + 7 × 105 + 70 m) by using Midas/civil to establish a finite element model. In this pa- per, the bending moment and shearing force of the traveling wave effect on the seismic response of the bridge were compared under different combinations between two types of seismic waves and three types of apparent wave velocity. The calculation and analysis show that the input of different seismic waves has great difference in its influence on the bending moment and shearing force; the influence of the traveling wave effect on the internal force of the seismic response of the bridge is different in extent and tendency. But with the increase of the ap- parent velocity, the influence of the traveling wave effect on the internal force is reduced and the bending mo- ment is reduced by 17.11% when the apparent wave velocity is 500 m/s, reduced by 11.22% when the apparent wave velocity is 800 m/s, and reduced by 8.83% when the apparent wave velocity is 1 000 m/s. Besides, this change has certain regularity in the longitudinal bridge.