Based on relevant data of 20 provinces in mid-western regions from 2006 to 2015, this paper estab- lishes a coordinated development validity evaluation model and carries out an empirical analysis on coordinated development of railway and highway logistics in mid-western regions by using DEA method. The research results show that there is an obvious imbalance in the coordinated development of railway and highway logistics in vari- ous provinces of mid-western regions. In recent ten years, the internal coordinated development of railway and highway logistics subsystems is at medium level, and many provinces have diminishing returns and there is ob- vious redundancy in terms of logistics input. The overall level of coordinated development between railway and highway logistics system is not high and presents a trend of decline with fluctuation. Most provinces are in a low or highly incongruous state. According to the research results, this paper proposed corresponding strategies and suggestions.