Three groups of self -tapping screw roof slabs were tested to investigate the influence of material strength and fixed position of roof slabs on the wind resistance of self-tapping screw roof slabs. The test results show that with the increase of the strength of the metal roof panel, the wind resistance of the self-tapping screw- type metal roof panel increases significantly, while the location of the self-tapping screw(at a quarter of the peak and trough) has little effect on the wind resistance of the roof panel system; when the self-tapping screw is at the peak, the wind resistance of the self-tapping screw is at a quarter of the trough according to the code and the formula calculation is safe.