Under the background of the maturity of wind power generation technology and grid-integrated tech- nology as well as energy saving and emission reduction, a multi-objective dynamic environmental economic dis- patch model of power system with large-scale wind power integration is constructed. The model aims at the total fuel cost and pollution emission of thermal power units, and takes into account the power balance constraints, active power output constraints, climbing constraints and the positive and negative spinning reserve constraints of the system. The constructed model is solved by non-dominated sorting molecular differential evolution algorithm. Finally, the rationality and superiority of the proposed model and algorithm are verified by an example analysis.