The railway logistics center is the hub connecting the railway freight and the outside world. Its internal layout is related to the efficiency of the operation of goods in it, which has a crucial impact on the fluency of the entire railway freight. Based on the functional division of the railway logistics center, this paper compares and analyzes the layout method of the functional area, and proposes a functional area layout method based on improved SLP. Taking the maximum mutual relationship and the minimum overall transportation cost as the optimization goal, the two aspects of the function are constrained, the multi-objective optimization model is established, and the NSGA -Ⅱ is used to solve the problem, and the optimal solution set is obtained. Finally, the AHP fuzzy comprehensive evaluation method is used to compare and evaluate, and the optimal layout scheme is selected. Taking the S city railway logistics center as an example, the scientific and feasibility of the method are verified.