Relying on a slope project in a reservoir area, through on-site hydrogeological survey and laboratory tests, to master the geotechnical engineering properties of the bank slope, combined with dry and wet cycle tests, theoretical analysis and numerical simulation software, to study the water storage period of the project and the water level after operation Reservoir bank slope stability under dynamic ups and downs. The results show that the groundwater infiltration line is "concave" at high water levels and "convex" at low water levels. As the water level of the reservoir area rises, the stability of the slope will also increase, and when the water level gradually falls, the stability of the slope will decrease, and eventually the stability of the slope will be lower than that of the slope that has not experienced the change of water level. The water level in the reservoir area can be regarded as the safe water level range between the normal storage level of 30m and the highest storage level of 36m. This study can provide a reference for the slope protection of the reservoir area and the water level scheduling scheme in the reservoir area.