It is necessary for China ' s economic development to maintain high quality of economic development.In view of this, the panel data of 157 prefecture level cities in the provinces along the Long March from 2006 to2017 were selected to analyze the relationship between environmental regulation policy and high -quality eco-nomic development. The results show that: environmental regulation has a significant positive effect on high -quality economic development, but from a regional point of view, there are obvious regional differences in the ef-fect relationship between them. In the eastern region, environmental regulation shows a binding effect on high-quality economic development, while it shows a promoting effect on the central and western regions. At the sametime, investment in fixed assets has a general inhibitory effect on high-quality economic development, while thenumber of employees on duty has a generally positive effect on high -quality economic development. Based onthis, the local governments along the Long March should implement environmental regulations according to localconditions, strengthen the implementation of environmental policies, and pay attention to improving the quality oflabor force and optimizing and upgrading the industrial structure.