Ascertaining the material flow rule, avoding the macro forming defects and disclosing the microstructure evolution in the isothermal local forging (ILF) have great significance for realizing integrated less-loading forming of shape and performance for aeronautical large-scale titanium alloy bulkhead. To this end, the research of macro and micro forming on ILF are reviewed. Firstly, the trans-regional material flow behaviour under the interaction of multi -deformation zones were elaborated. Secondly, the formation mechanisms and improvement measures of the forming defects by the ILF were given. Subsquently, the distribution of primary α-phase recrystallization and its grain size were predicted. Finally, the conclusions were given as well as the problems and challenges in ILF field were pointed out.