【Objective】The influence of blasting excavation of underground cavern group on the safety and stability of adjacent cavern was researched.【Method】Based on an underground reserve project, this study carried out an analysis of the influence of blasting excavation of underground cavern group dome on adjacent cavern, and the influence of different burial depths on the dynamic response of adjacent cavern was studied.【Result】 The result shows that the blasting excavation conditions of branch tunnel are in the relationship of up or down tunneling, and the displacement response and vibration velocity response are mainly in the vertical direction. The shear stress of the main tunnel mainly extends to the hance, and the maximum shear stress appears near the middle of the straight wall, but it is still within the tensile strength range of the surrounding rock of the main tunnel.During blasting excavation of the outer ring of the dome, the vibration velocity and displacement response of the corresponding inner circle structure are larger. The vault and hance are in the horizontal direction, and the skewback is in the vertical direction. The maximum tensile stress and shear stress appear in the surrounding rock near the arch foot.【Conclusion】Steel supports can be set at the junction of the dome inner circle and outer ring to strengthen the stability of the dome inner circle structure. When the cavity is in deep burial state, under the same blasting conditions, the burial depth has almost no influence on the vibration velocity response of the adjacent cavity.