Aiming at the problem that the stress of each pile is different when the pile-soil coupling anti-slide pile is used to support the slope, taking a landslide control project in Jiangxi Province as the background, the Midas GTS NX finite element software is used to establish the pile-soil coupling anti-slide pile treatment model. The internal force and displacement variation of the structure under different pile length combinations are discussed, and the stress and deformation characteristics of the pile under different reinforcement methods are analyzed. The results show that the decrease of the anchorage ratio of the middle and rear piles will lead to the increase of the displacement and internal force of the front pile, and the decrease of the anchorage ratio of the pile will significantly reduce the bending moment and shear force. When the anchoring ratio of the rear pile is less than 1/3, the landslide thrust will not be transmitted to the stable stratum through the pile. By comparing the three reinforcement schemes, it is found that under the condition of meeting the safety requirements, the unified reinforcement of the pile is larger, the deformation of the pile is small, and the treatment effect and structural strength are better. When supporting a slope with a single load, the reinforcement method considering the force characteristics of the pile body is preferred. When supporting slopes with complex loads, the design method of separate reinforcement in each row is preferred.