In order to understand the change of internal temperature stress of the pavement in the cold region of Inner Mongolia and study the temperature stress behavior and structural performance for different base pavement in the cold region, this paper obtained the temperature stress of pavement in large temperature difference environment with daily temperature difference of 20 ℃, 30 ℃ and 40 ℃ by using Abaqus software and the sequential coupled-field method. The mechanical response of different base pavement under the coupled effect of dynamic load was analyzed. The results show that the combined base pavement has the best mechanical performance in the cold region with large temperature difference, and still has the advantage under the coupling effect of temperature and dynamic load. The temperature stress of each layer is the minimum, and all mechanical indexes are small under the coupling effect of low temperature and dynamic load, and the shear stress of asphalt layer is better under the coupling effect of high temperature and dynamic load.