In order to study the dynamical response of heavy trucks collision with piers at different speeds, the nonlinear dynamic analysis was carried out by using the finite element software LS-DYNA. Considering the influence of superstructure on collision process, the superstructure was simulated by mass block. Taking Dongfeng Tianlong heavy truck as a prototype to establish a finite element model. The weight of 30，40，50 t vehicles were simulated at 50，80，110 km / h respectively, and the influence of impact velocity and impact mass on pier displacement and collision force was obtained. The law of energy variation with time was analyzed to verify the rationality of the finite element model. The peak value of collision force was compared with the relevant literature and codes. The results show that the current anti-collision design code is difficult to meet the requirement of bridge collision prevention in practical engineering.