The truck drivers in highway transportation were chosen as the study objects. Based on the investiga-tion of four transportation enterprises and the existing research results， the accident tree model of the drivers’ fault was established and analyzed. Finally， some suggestions for preventing drivers’ fault were proposed. Re-search results show that road traffic accidents due to the truck drivers’ faults happen easily with great hazards and few controllable approaches. It maintains that such factors as tension， alcohol， fatigue， medicine and dis- ease often result in faults of the truck drivers.