Based on the experimental result of eight concrete columns (including one unreinforced specimen and seven strengthened specimens with prestressed high strength steel wire mesh) under low cyclic loading, this pa- per, by calculating the hysteretic curve, skeleton curve and ductility change of specimens in terms of different factors, analyzed the effects of such factors as steel strand space, prestressing level and axial compression ratio on the seismic behavior of the strengthened columns. The research results show that within the prestressing level range of 0~60%, with the increase of prestressing level, the yield load, ultimate load, displacement ductility co- efficient of the reinforced concrete columns increased by 4.4%~30.6%, 16.4%~60.4% and 8.2%~49.8%. The yield load, ultimate load ductility coefficient and displacement ductility coefficient of the reinforced specimens with strand spacing of 30mm were 7.0%~10.9%, 17.0%~25.1% and 15.1%~35.2% greater than those of the re- inforced specimens with strand spacing of 60mm respectively.