The characteristics of hot-in-place recycling technology include open construction, unstable construc- tion temperature, uneven gradation and asphalt properties, which cause the pavement quality to be greatly influ- enced by three factors such as rolling temperature, rejuvenators and warm mixing agent. The key problem of pavement quality is moisture stability, whose main indexes include the freeze-thaw splitting tensile strength, the splitting tensile strength, and the freeze-thaw splitting tensile strength ratio. The orthogonal test method was used to calculate the degree of influence of factors by using the range and variance analysis, and the change rule of the evaluation factors and moisture stability was evaluated by the regression of the nonlinear model. The results showed that effects on freeze-thaw splitting tensile strength and splitting tensile strength ranked as rolling tem- perature > rejuvenators > warm mixing agent. However, effects on freeze -thaw splitting tensile strength ratio ranked as rejuvenators > warm mixing agent > rolling temperature. The cross model was used to regress the rela- tionship among rolling temperature, rejuvenators, warm mixing agent and water stability index, which may be ap- plied to measure the actual rolling temperature at the site and estimate the optimum content of rejuvenators and warm mixing agent to ensure the moisture stability of recycled asphalt pavement to meet the requirements.