Railway crossing safety is an important link for ensuring the safety management of railway operation. However, there are many influencing factors and management difficulties, which make it difficult to prevent re- lated accidents. Aiming at the frequent occurrence of railway crossing accidents, this paper analyzed these five main factors causing the crossing accident safety, such as people, vehicles, crossing characteristics, safety pro- tection devices and environment. Then, it established the crossing safety evaluation index system, introduced the principle of multiple connection number set pair analysis, established the application model of multiple connec- tion number set pair analysis method in crossing safety evaluation, and took China Railway X Bureau Group Co., Ltd., as an example. Based on the background of the railway crossing under the jurisdiction of this unit, the "sit- uation" of crossing safety was probed into and the applicability of the model was verified, and a new method for quantitatively judging the crossing safety evaluation system was proposed.