The multi-Agent system can effectively solve distribution problems, and the electric power system belongs to the distributed structure. This paper takes the intelligent substation as the research object, combines the Agent technology with IEC61850 standard, and analyzes how the Agent technology is used to solve the possible conflicts of IEC61850 communication. In the same LAN, IED device is used as Agent to avoid communication confusion by implementing multi-Agent autonomous algorithm coordination system, setting message filtering and creating polling Agent. Between different LANs, the complex distributed communication problem of substation is solved by using TCP/IP protocol to transmit messages, which has high practical value.