Based on the finite element-statistical energy (FE-SEA) hybrid method, this paper establishes a steelconcrete composite beam bridge model, and predicts the vibration response and structural noise of each plate of the bridge under the conditions of train running speed of 200 km/h and trains crossing. The results show that when trains cross：The vibration acceleration level at the midpoint of each plate increases, the dominant frequency band is 40~120 Hz, and the peak frequency is 65 Hz. In the whole frequency band, the sound pressure level of each plate increases; the peak frequency of the sound pressure level of each plate in the two states of one-way driving and train crossing is at 500 Hz, and the pattern of changes for sound pressure level of the web and the lower flange are similar. The energy level of each plate of the bridge increases in the whole frequency band, and the energy level of the web is the largest. When the frequency is 100 Hz, the vibration energy level of the web and the lower flange has an inflection point, indicating that this frequency has the greatest impact on the energy level.