In recent years, the integrity of railway scientific research has aroused concern from all walks of life. In order to analyze the integrity of railway scientific research in China, based on the Triple Helix Model and centered on the credibility of railway scientific research personnel, the cooperative relationship among universities, government and enterprises is expounded. This paper analyzes the status quo of scientific research integrity in China and the scientific research integrity in railway industry. From the aspects of system construction, moral construction and information management construction, this paper discusses the problems of the integrity of railway scientific research in China and puts forward some suggestions. The management of scientific research misconduct should start from system, education and big data technology, and build a governance model of "government, industry and learning".