In order to study the characteristics of indoor vibration and secondary noise of buildings induced by 160 km/h urban subway, a long-term monitoring system was deployed in a building room along a new urban express line to carry out long-term vibration and noise monitoring. Based on the analysis of a large number of monitoring data,the characteristics of indoor vibration and secondary structural noise of buildings along the highspeed underground line are studied,and the changes of vibration and noise characteristics at different driving speeds are studied. The analysis results show that each frequency band of indoor vibration induced by subway has a certain degree of dispersion. In the 25.0~125.0 Hz frequency band,the dispersion degree of the frequency-divided vibration level is lower than that of other frequency bands. The dispersion of the frequency-divided sound pressure level of each frequency band of indoor secondary structural noise induced by subway is significantly greater than that of the frequency-divided vibration level of indoor vibration induced by subway. The difference between secondary structural noise and background noise is mainly concentrated in the 31.5~125.0 Hz frequency band. The correlation between the vibration frequency-divided vibration level and the secondary structural noise frequency-divided sound pressure level in the subway-induced room is large in the frequency band of 31.5~100.0 Hz. After the speed increases, the correlation between the vibration level and the secondary structural noise does not increase significantly, but the dispersion degree of the vibration and secondary structural noise monitoring data decreases. After the speed increases, the vibration frequency division vibration level increases at 20.0~50.0 Hz, while the secondary noise sound pressure level of the structure increases only at 31.5 Hz.