In order to obtain the safety performance index that is most suitable for the performance evaluation of high- speed trains passing through turnouts under crosswind, the operation safety domains of high- speed trains passing through turnouts in straight and side reverse directions under crosswind are proposed. By establishing the aerodynamic model of high-speed trains passing through turnouts and the dynamic model of crosswind-trainturnout coupling multi- body system, the safety of high- speed trains passing through turnouts under crosswind was deeply explored. The results show that under the action of crosswind, the pressure on the windward side increases significantly, and the obvious pressure difference is formed on both sides of the head car, which makes the head car more prone to derailment and rollover during operation. When the high-speed train passes through the turnout directly and reversely, when the crosswind wind speed is not more than 15 m/s, the high-speed train can pass through the turnout at a speed of 250 km/h; when the crosswind speed reaches 20 m/s and above, the speed of the high-speed train should be less than 250 km/h. When the crosswind speed is greater than 15 m/s, the speed of the high-speed train side should be less than 80 km/h. Under the action of crosswind, the head car is more prone to derailment and rollover when the high-speed train runs. When the high-speed train passes through the turnout directly and reversely, when the crosswind speed reaches 8 and above, the speed of the train passing through the turnout should be less than 250 km/h. When the side of the high-speed train passes through the turnout reversely, when the crosswind speed reaches 7 and above, the speed of the train passing through the turnout should be less than 80 km/h. The research results can provide reference for the smoothness and safety of highspeed trains passing through turnouts under different crosswind conditions.